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The 100 most highly cited papers of all time

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To mark the anniversary, Nature magazine asked Thomson Reuters to list the 100 most highly cited papers of all time. The search covered all of Thomson Reuter’s Web of Science, an online version of the SCI that also includes databases covering the social sciences, arts and humanities, conference proceedings and some books. It lists papers published from 1900 to the present day.

 
Title of the paperRankSujet
The assessment and analysis of handedness: the Edinburgh inventory.61Psychology/psychiatryVoir plus
Estimation of concentration of low-density lipoprotein cholesterol in plasma - without use of preparative ultracentrifuge.62MedicineVoir plus
Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase.63Biology lab techniqueVoir plus
Multiple range and multiple F tests.64Mathematics/statisticsVoir plus
Electric field effect in atomically thin carbon films.65PhysicsVoir plus
Tissue sulfhydryl groups.66Biology lab techniqueVoir plus
Isolation of mononuclear cells and granulocytes from human blood.67Biology lab techniqueVoir plus
The measurement of observer agreement for categorical data.68Mathematics/statisticsVoir plus
Crystallography & NMR system: a new software suite for macromolecular structure determination.69CrystallographyVoir plus
Gaussian-basis sets for use in correlated molecular calculations. 1. The atoms boron through neon and hydrogen.70Mathematics/statisticsVoir plus
PROCHECK: a program to check the stereochemical quality of protein structures.71CrystallographyVoir plus
The MOS 36-item short-form health survey (SF-36): I. Conceptual framework and item selection.72MedicineVoir plus
A new look at statistical-model identification.73Mathematics/statisticsVoir plus
Improved M13 phage cloning vectors and host strains — nucleotide-sequences of the M13mp18 and pUC19 vectors74Biology lab techniqueVoir plus
A comprehensive set of sequence-analysis programs for the vax.75BioinformaticsVoir plus
MODELTEST: Testing the model of DNA.76BioinformaticsVoir plus
From ultrasoft pseudopotentials to the projector augmented-wave method.77Physical chemistryVoir plus
Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures.78Biology lab techniqueVoir plus
Comparison of simple potential functions for simulating liquid water.79Biology lab techniqueVoir plus
The development and use of quantum-mechanical molecular-models. 76. AM1: a new general-purpose quantum-mechanical molecular-model80Physical chemistryVoir plus
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